Overview

Predicted structure (AF):

AF-P84243-F1-model_v4

Uniprot entry:

P84243

Gene:

P84243

Protein length:

136 residues

Mutation:

Q → H

Mutation position:

6

D2Deep Prediction:

0.002

Overall confidence:

0.730

Pred. interpretation:

Benign based on D2Deep prediction

 

Benign

Pathogenic

Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".

Sequence difference

	1	2	3	4	5	6	7	8	9	10	11
Original	M	A	R	T	K	Q	T	A	R	K	S
Target	M	A	R	T	K	H	T	A	R	K	S

Differences at amino acid level

Feature	Original «Q»	Target «H»
Name	Glutamine (Gln)	Histidine (His)
Molecular Formula	C5H10N2O3	C6H9N3O2
Residue Formula	C5H8N2O	C6H7N3O
Molecular Weight	146.150	155.160 (+9.010)
Residue Weight	128.130	137.140 (+9.010)
Hydrophobicity index at pH 2	Neutral	Hydrophilic
Hydrophobicity index at pH 7	Neutral	Neutral
Charge	Neutral	Positive
Solutibility	2.600	4.190
Structure Image
Description	Glutamine (Gln) is the most abundant amino acid in human bodies, and it performs several functions. It is responsible for regulating toxic ammonia and urea in human bodies. The reason glutamine can remove toxic ammonia is because its carboxyl side chain can act as a donor and acceptor for ammonia (this then allows for the safe transport of ammonia in human bodies).	Histidine (His) within proteins acts as both a proton acceptor and donor. Due to this property, histidine can combine into enzymes involved in the metabolism of proteins, carbohydrates, and nucleic acids.