P11802 (CDK4)

Overview
Predicted structure (AF):
AF-P11802-F1-model_v4
Uniprot entry:
P11802
Gene:
CDK4
Protein length:
303 residues
Mutations found:
5756
Benign based on D2Deep prediction:
3605 out of 5756 mutations
Pathogenic based on D2Deep prediction:
2151 out of 5756 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 5756 mutations across 303 unique positions. There are 3605 benign and 2151 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
1 M 17 1 18 0.192 0.731 View mutations
2 A 9 10 19 0.491 0.474 View mutations
3 T 15 4 19 0.189 0.758 View mutations
4 S 19 0 19 0.003 0.985 View mutations
5 R 19 0 19 0.024 0.910 View mutations
6 Y 19 0 19 0.076 0.663 View mutations
7 E 19 0 19 0.002 0.674 View mutations
8 P 19 0 19 0.035 0.675 View mutations
9 V 15 4 19 0.279 0.534 View mutations
10 A 18 1 19 0.060 0.513 View mutations
11 E 17 2 19 0.129 0.646 View mutations
12 I 10 9 19 0.416 0.441 View mutations
13 G 18 1 19 0.112 0.422 View mutations
14 V 15 4 19 0.262 0.587 View mutations
15 G 19 0 19 0.044 0.452 View mutations
16 A 19 0 19 0.000 0.443 View mutations
17 Y 11 8 19 0.377 0.436 View mutations
18 G 1 18 19 0.893 0.595 View mutations
19 T 3 16 19 0.822 0.464 View mutations
20 V 13 6 19 0.313 0.439 View mutations
21 Y 1 18 19 0.948 0.417 View mutations
22 K 0 19 19 0.995 0.507 View mutations
23 A 0 19 19 1.000 0.566 View mutations
24 R 0 19 19 0.968 0.376 View mutations
25 D 5 14 19 0.728 0.349 View mutations