P11802 (CDK4)

Overview
Predicted structure (AF):
AF-P11802-F1-model_v4
Uniprot entry:
P11802
Gene:
CDK4
Protein length:
303 residues
Mutations found:
5756
Benign based on D2Deep prediction:
3605 out of 5756 mutations
Pathogenic based on D2Deep prediction:
2151 out of 5756 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5756 mutations across 303 unique positions. There are 3605 benign and 2151 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 I 3 16 19 0.786 0.450 View mutations
52 S 7 12 19 0.630 0.437 View mutations
53 T 2 17 19 0.901 0.427 View mutations
54 V 9 10 19 0.516 0.507 View mutations
55 R 19 0 19 0.016 0.415 View mutations
56 E 2 17 19 0.888 0.682 View mutations
57 V 0 19 19 0.953 0.664 View mutations
58 A 15 4 19 0.202 0.473 View mutations
59 L 6 13 19 0.653 0.504 View mutations
60 L 3 16 19 0.830 0.570 View mutations
61 R 7 12 19 0.637 0.507 View mutations
62 R 4 15 19 0.765 0.430 View mutations
63 L 11 8 19 0.398 0.423 View mutations
64 E 14 5 19 0.300 0.422 View mutations
65 A 18 1 19 0.092 0.611 View mutations
66 F 16 3 19 0.202 0.468 View mutations
67 E 11 8 19 0.454 0.449 View mutations
68 H 2 17 19 0.833 0.538 View mutations
69 P 19 0 19 0.002 0.330 View mutations
70 N 19 0 19 0.032 0.448 View mutations
71 V 1 18 19 0.943 0.626 View mutations
72 V 1 18 19 0.888 0.636 View mutations
73 R 7 12 19 0.622 0.438 View mutations
74 L 7 12 19 0.638 0.526 View mutations
75 M 15 4 19 0.188 0.430 View mutations