P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
1 M 3 15 18 0.844 0.383 View mutations
2 A 12 7 19 0.396 0.502 View mutations
3 G 11 8 19 0.456 0.491 View mutations
4 Y 8 11 19 0.540 0.430 View mutations
5 L 4 15 19 0.762 0.362 View mutations
6 R 19 0 19 0.037 0.657 View mutations
7 V 19 0 19 0.017 0.682 View mutations
8 V 15 4 19 0.287 0.614 View mutations
9 R 19 0 19 0.026 0.733 View mutations
10 S 18 1 19 0.075 0.696 View mutations
11 L 19 0 19 0.045 0.707 View mutations
12 C 19 0 19 0.021 0.698 View mutations
13 R 17 2 19 0.100 0.695 View mutations
14 A 19 0 19 0.025 0.747 View mutations
15 S 19 0 19 0.039 0.742 View mutations
16 G 16 3 19 0.101 0.647 View mutations
17 S 18 1 19 0.130 0.701 View mutations
18 R 16 3 19 0.171 0.677 View mutations
19 P 17 2 19 0.128 0.708 View mutations
20 A 13 6 19 0.343 0.590 View mutations
21 W 13 6 19 0.351 0.595 View mutations
22 A 18 1 19 0.112 0.794 View mutations
23 P 9 10 19 0.565 0.458 View mutations
24 A 18 1 19 0.094 0.762 View mutations
25 A 18 1 19 0.066 0.754 View mutations