P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 V 1 18 19 0.948 0.429 View mutations
52 E 1 18 19 0.936 0.422 View mutations
53 M 2 17 19 0.897 0.452 View mutations
54 D 5 14 19 0.729 0.428 View mutations
55 G 19 0 19 0.001 0.427 View mutations
56 D 0 19 19 0.999 0.621 View mutations
57 E 0 19 19 1.000 0.616 View mutations
58 M 17 2 19 0.127 0.482 View mutations
59 T 12 7 19 0.362 0.491 View mutations
60 R 13 6 19 0.446 0.403 View mutations
61 I 1 18 19 0.937 0.350 View mutations
62 I 1 18 19 0.929 0.385 View mutations
63 W 12 7 19 0.306 0.440 View mutations
64 Q 19 0 19 0.045 0.698 View mutations
65 F 18 1 19 0.049 0.775 View mutations
66 I 4 15 19 0.693 0.447 View mutations
67 K 10 9 19 0.431 0.449 View mutations
68 E 18 1 19 0.061 0.647 View mutations
69 K 19 0 19 0.005 0.709 View mutations
70 L 19 0 19 0.000 0.405 View mutations
71 I 5 14 19 0.737 0.504 View mutations
72 L 19 0 19 0.052 0.483 View mutations
73 P 1 18 19 0.946 0.592 View mutations
74 H 19 0 19 0.014 0.475 View mutations
75 V 19 0 19 0.073 0.424 View mutations