P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
26 L 17 2 19 0.190 0.717 View mutations
27 T 18 1 19 0.079 0.756 View mutations
28 A 19 0 19 0.046 0.818 View mutations
29 P 19 0 19 0.006 0.812 View mutations
30 T 19 0 19 0.005 0.841 View mutations
31 S 16 3 19 0.173 0.721 View mutations
32 Q 16 3 19 0.221 0.685 View mutations
33 E 18 1 19 0.083 0.800 View mutations
34 Q 15 4 19 0.245 0.705 View mutations
35 P 19 0 19 0.016 0.842 View mutations
36 R 19 0 19 0.030 0.898 View mutations
37 R 18 1 19 0.078 0.833 View mutations
38 H 19 0 19 0.005 0.892 View mutations
39 Y 18 1 19 0.044 0.829 View mutations
40 A 19 0 19 0.002 0.868 View mutations
41 D 19 0 19 0.021 0.865 View mutations
42 K 19 0 19 0.000 0.843 View mutations
43 R 19 0 19 0.000 0.746 View mutations
44 I 16 3 19 0.146 0.536 View mutations
45 K 19 0 19 0.024 0.810 View mutations
46 V 18 1 19 0.055 0.635 View mutations
47 A 19 0 19 0.028 0.771 View mutations
48 K 19 0 19 0.009 0.662 View mutations
49 P 17 2 19 0.202 0.520 View mutations
50 V 2 17 19 0.908 0.394 View mutations