P61073 (CXCR4)

Overview
Predicted structure (AF):
AF-P61073-F1-model_v4
Uniprot entry:
P61073
Gene:
CXCR4
Protein length:
352 residues
Mutations found:
6687
Benign based on D2Deep prediction:
2592 out of 6687 mutations
Pathogenic based on D2Deep prediction:
4095 out of 6687 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 6687 mutations across 352 unique positions. There are 2592 benign and 4095 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
1 M 18 0 18 0.000 0.685 View mutations
2 E 19 0 19 0.025 0.903 View mutations
3 G 12 7 19 0.352 0.591 View mutations
4 I 18 1 19 0.058 0.870 View mutations
5 S 18 1 19 0.044 0.918 View mutations
6 I 19 0 19 0.001 0.933 View mutations
7 Y 19 0 19 0.000 0.932 View mutations
8 T 19 0 19 0.000 0.963 View mutations
9 S 18 1 19 0.054 0.917 View mutations
10 D 18 1 19 0.051 0.869 View mutations
11 N 19 0 19 0.004 0.878 View mutations
12 Y 18 1 19 0.080 0.926 View mutations
13 T 19 0 19 0.008 0.951 View mutations
14 E 17 2 19 0.150 0.850 View mutations
15 E 19 0 19 0.002 0.941 View mutations
16 M 19 0 19 0.000 1.000 View mutations
17 G 13 6 19 0.294 0.644 View mutations
18 S 4 15 19 0.715 0.232 View mutations
19 G 11 8 19 0.469 0.548 View mutations
20 D 19 0 19 0.034 0.910 View mutations
21 Y 14 5 19 0.259 0.690 View mutations
22 D 19 0 19 0.048 0.939 View mutations
23 S 18 1 19 0.088 0.896 View mutations
24 M 18 1 19 0.065 0.858 View mutations
25 K 18 1 19 0.088 0.761 View mutations