Q04771 (ACVR1)

Overview
Predicted structure (AF):
AF-Q04771-F1-model_v4
Uniprot entry:
Q04771
Gene:
ACVR1
Protein length:
509 residues
Mutations found:
9670
Benign based on D2Deep prediction:
5151 out of 9670 mutations
Pathogenic based on D2Deep prediction:
4519 out of 9670 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 9670 mutations across 509 unique positions. There are 5151 benign and 4519 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
426 D 19 0 19 0.000 0.258 View mutations
427 Y 0 19 19 1.000 0.770 View mutations
428 K 0 19 19 0.964 0.714 View mutations
429 P 2 17 19 0.919 0.752 View mutations
430 P 1 18 19 0.946 0.810 View mutations
431 F 3 16 19 0.857 0.705 View mutations
432 Y 6 13 19 0.625 0.591 View mutations
433 D 17 2 19 0.118 0.240 View mutations
434 V 15 4 19 0.275 0.398 View mutations
435 V 18 1 19 0.044 0.176 View mutations
436 P 18 1 19 0.064 0.220 View mutations
437 N 18 1 19 0.063 0.348 View mutations
438 D 0 19 19 0.999 0.914 View mutations
439 P 4 15 19 0.743 0.759 View mutations
440 S 0 19 19 1.000 0.935 View mutations
441 F 0 19 19 1.000 0.893 View mutations
442 E 12 7 19 0.355 0.397 View mutations
443 D 3 16 19 0.821 0.786 View mutations
444 M 0 19 19 1.000 0.938 View mutations
445 R 2 17 19 0.895 0.763 View mutations
446 K 14 5 19 0.289 0.379 View mutations
447 V 1 18 19 0.949 0.759 View mutations
448 V 0 19 19 0.984 0.826 View mutations
449 C 1 18 19 0.927 0.718 View mutations
450 V 14 5 19 0.313 0.431 View mutations