O75204 (TMEM127)

Overview
Predicted structure (AF):
AF-O75204-F1-model_v4
Uniprot entry:
O75204
Gene:
TMEM127
Protein length:
238 residues
Mutations found:
4521
Benign based on D2Deep prediction:
2714 out of 4521 mutations
Pathogenic based on D2Deep prediction:
1807 out of 4521 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4521 mutations across 238 unique positions. There are 2714 benign and 1807 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
226 V 12 7 19 0.366 0.449 View mutations
227 I 19 0 19 0.065 0.501 View mutations
228 N 12 7 19 0.389 0.430 View mutations
229 Q 0 19 19 0.999 0.461 View mutations
230 F 3 16 19 0.851 0.517 View mutations
231 Q 3 16 19 0.795 0.438 View mutations
232 P 0 19 19 0.987 0.598 View mutations
233 P 0 19 19 1.000 0.595 View mutations
234 P 0 19 19 1.000 0.591 View mutations
235 A 1 18 19 0.910 0.567 View mutations
236 Y 0 19 19 1.000 0.587 View mutations
237 T 3 16 19 0.804 0.540 View mutations
238 P 1 18 19 0.870 0.548 View mutations