O75204 (TMEM127)

Overview
Predicted structure (AF):
AF-O75204-F1-model_v4
Uniprot entry:
O75204
Gene:
TMEM127
Protein length:
238 residues
Mutations found:
4521
Benign based on D2Deep prediction:
2714 out of 4521 mutations
Pathogenic based on D2Deep prediction:
1807 out of 4521 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4521 mutations across 238 unique positions. There are 2714 benign and 1807 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
201 T 16 3 19 0.123 0.259 View mutations
202 E 17 2 19 0.189 0.153 View mutations
203 E 16 3 19 0.244 0.199 View mutations
204 E 7 12 19 0.503 0.607 View mutations
205 E 17 2 19 0.211 0.232 View mutations
206 Q 18 1 19 0.083 0.379 View mutations
207 A 18 1 19 0.106 0.204 View mutations
208 L 13 6 19 0.342 0.415 View mutations
209 E 16 3 19 0.339 0.346 View mutations
210 L 14 5 19 0.259 0.400 View mutations
211 L 11 8 19 0.375 0.476 View mutations
212 S 6 13 19 0.636 0.526 View mutations
213 E 6 13 19 0.591 0.533 View mutations
214 M 5 14 19 0.639 0.519 View mutations
215 E 5 14 19 0.662 0.456 View mutations
216 E 9 10 19 0.565 0.444 View mutations
217 N 15 4 19 0.291 0.531 View mutations
218 E 7 12 19 0.551 0.432 View mutations
219 P 18 1 19 0.048 0.542 View mutations
220 Y 19 0 19 0.031 0.502 View mutations
221 P 18 1 19 0.105 0.568 View mutations
222 A 17 2 19 0.121 0.607 View mutations
223 E 18 1 19 0.069 0.407 View mutations
224 Y 16 3 19 0.276 0.523 View mutations
225 E 10 9 19 0.508 0.427 View mutations