O75204 (TMEM127)

Overview
Predicted structure (AF):
AF-O75204-F1-model_v4
Uniprot entry:
O75204
Gene:
TMEM127
Protein length:
238 residues
Mutations found:
4521
Benign based on D2Deep prediction:
2714 out of 4521 mutations
Pathogenic based on D2Deep prediction:
1807 out of 4521 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 4521 mutations across 238 unique positions. There are 2714 benign and 1807 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
176 S 18 1 19 0.156 0.129 View mutations
177 F 19 0 19 0.014 0.095 View mutations
178 Y 19 0 19 0.002 0.097 View mutations
179 L 19 0 19 0.049 0.110 View mutations
180 V 19 0 19 0.042 0.096 View mutations
181 A 19 0 19 0.010 0.171 View mutations
182 G 19 0 19 0.003 0.134 View mutations
183 A 14 5 19 0.298 0.308 View mutations
184 G 19 0 19 0.000 0.084 View mutations
185 G 18 1 19 0.035 0.177 View mutations
186 A 12 7 19 0.388 0.413 View mutations
187 S 10 9 19 0.505 0.479 View mutations
188 I 18 1 19 0.084 0.209 View mutations
189 L 11 8 19 0.379 0.427 View mutations
190 A 2 17 19 0.878 0.807 View mutations
191 T 2 17 19 0.805 0.797 View mutations
192 A 15 4 19 0.255 0.262 View mutations
193 A 10 9 19 0.502 0.479 View mutations
194 N 0 19 19 0.997 0.976 View mutations
195 L 2 17 19 0.837 0.872 View mutations
196 L 7 12 19 0.601 0.632 View mutations
197 R 1 18 19 0.823 0.858 View mutations
198 H 9 10 19 0.504 0.525 View mutations
199 Y 12 7 19 0.356 0.381 View mutations
200 P 19 0 19 0.123 0.014 View mutations