P01116-2 (KRAS)

Overview
Predicted structure (AF):
AF-P01116-2-F1-model_v4
Uniprot entry:
P01116-2
Gene:
KRAS
Protein length:
188 residues
Mutations found:
3571
Benign based on D2Deep prediction:
2136 out of 3571 mutations
Pathogenic based on D2Deep prediction:
1435 out of 3571 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 3571 mutations across 188 unique positions. There are 2136 benign and 1435 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
1 M 18 0 18 0.000 0.648 View mutations
2 T 19 0 19 0.044 0.820 View mutations
3 E 1 18 19 0.962 0.176 View mutations
4 Y 9 10 19 0.525 0.451 View mutations
5 K 5 14 19 0.677 0.409 View mutations
6 L 19 0 19 0.020 0.451 View mutations
7 V 19 0 19 0.024 0.517 View mutations
8 V 19 0 19 0.031 0.522 View mutations
9 V 4 15 19 0.788 0.430 View mutations
10 G 1 18 19 0.956 0.556 View mutations
11 A 12 7 19 0.345 0.483 View mutations
12 G 0 19 19 1.000 0.550 View mutations
13 G 1 18 19 0.957 0.569 View mutations
14 V 0 19 19 1.000 0.627 View mutations
15 G 18 1 19 0.059 0.401 View mutations
16 K 19 0 19 0.000 0.474 View mutations
17 S 1 18 19 0.928 0.430 View mutations
18 A 5 14 19 0.696 0.433 View mutations
19 L 6 13 19 0.675 0.416 View mutations
20 T 18 1 19 0.073 0.591 View mutations
21 I 0 19 19 0.983 0.266 View mutations
22 Q 15 4 19 0.213 0.558 View mutations
23 L 4 15 19 0.753 0.306 View mutations
24 I 6 13 19 0.686 0.380 View mutations
25 Q 1 18 19 0.921 0.313 View mutations