P01116-2 (KRAS)

Overview
Predicted structure (AF):
AF-P01116-2-F1-model_v4
Uniprot entry:
P01116-2
Gene:
KRAS
Protein length:
188 residues
Mutations found:
3571
Benign based on D2Deep prediction:
2136 out of 3571 mutations
Pathogenic based on D2Deep prediction:
1435 out of 3571 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 3571 mutations across 188 unique positions. There are 2136 benign and 1435 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 C 2 17 19 0.889 0.366 View mutations
52 L 4 15 19 0.743 0.378 View mutations
53 L 0 19 19 1.000 0.591 View mutations
54 D 1 18 19 0.930 0.525 View mutations
55 I 19 0 19 0.002 0.326 View mutations
56 L 6 13 19 0.727 0.597 View mutations
57 D 0 19 19 1.000 0.821 View mutations
58 T 8 11 19 0.661 0.579 View mutations
59 A 4 15 19 0.764 0.715 View mutations
60 G 0 19 19 0.982 0.907 View mutations
61 Q 0 19 19 1.000 0.654 View mutations
62 E 0 19 19 1.000 0.707 View mutations
63 E 13 6 19 0.373 0.460 View mutations
64 Y 5 14 19 0.674 0.457 View mutations
65 S 8 11 19 0.590 0.436 View mutations
66 A 1 18 19 0.891 0.604 View mutations
67 M 1 18 19 0.931 0.520 View mutations
68 R 0 19 19 0.977 0.519 View mutations
69 D 16 3 19 0.135 0.479 View mutations
70 Q 13 6 19 0.381 0.472 View mutations
71 Y 1 18 19 0.942 0.566 View mutations
72 M 4 15 19 0.746 0.512 View mutations
73 R 1 18 19 0.958 0.574 View mutations
74 T 3 16 19 0.838 0.465 View mutations
75 G 1 18 19 0.852 0.611 View mutations