P11802 (CDK4)

Overview
Predicted structure (AF):
AF-P11802-F1-model_v4
Uniprot entry:
P11802
Gene:
CDK4
Protein length:
303 residues
Mutations found:
5756
Benign based on D2Deep prediction:
3605 out of 5756 mutations
Pathogenic based on D2Deep prediction:
2151 out of 5756 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5756 mutations across 303 unique positions. There are 3605 benign and 2151 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
276 L 5 14 19 0.753 0.556 View mutations
277 T 19 0 19 0.006 0.486 View mutations
278 F 19 0 19 0.012 0.422 View mutations
279 N 16 3 19 0.287 0.525 View mutations
280 P 6 13 19 0.677 0.518 View mutations
281 H 13 6 19 0.347 0.503 View mutations
282 K 19 0 19 0.012 0.534 View mutations
283 R 19 0 19 0.005 0.430 View mutations
284 I 3 16 19 0.840 0.359 View mutations
285 S 17 2 19 0.140 0.450 View mutations
286 A 19 0 19 0.000 0.497 View mutations
287 F 19 0 19 0.000 0.634 View mutations
288 R 18 1 19 0.152 0.647 View mutations
289 A 19 0 19 0.031 0.361 View mutations
290 L 14 5 19 0.254 0.406 View mutations
291 Q 19 0 19 0.011 0.684 View mutations
292 H 2 17 19 0.879 0.387 View mutations
293 S 19 0 19 0.001 0.549 View mutations
294 Y 11 8 19 0.418 0.455 View mutations
295 L 19 0 19 0.000 0.589 View mutations
296 H 19 0 19 0.000 0.816 View mutations
297 K 19 0 19 0.005 0.806 View mutations
298 D 19 0 19 0.001 0.820 View mutations
299 E 19 0 19 0.003 0.816 View mutations
300 G 19 0 19 0.030 0.866 View mutations