P11802 (CDK4)

Overview
Predicted structure (AF):
AF-P11802-F1-model_v4
Uniprot entry:
P11802
Gene:
CDK4
Protein length:
303 residues
Mutations found:
5756
Benign based on D2Deep prediction:
3605 out of 5756 mutations
Pathogenic based on D2Deep prediction:
2151 out of 5756 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5756 mutations across 303 unique positions. There are 3605 benign and 2151 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
251 P 19 0 19 0.010 0.717 View mutations
252 R 19 0 19 0.000 0.678 View mutations
253 G 19 0 19 0.029 0.626 View mutations
254 P 19 0 19 0.001 0.561 View mutations
255 R 19 0 19 0.004 0.635 View mutations
256 P 19 0 19 0.015 0.705 View mutations
257 V 17 2 19 0.093 0.603 View mutations
258 Q 19 0 19 0.000 0.747 View mutations
259 S 19 0 19 0.005 0.679 View mutations
260 V 19 0 19 0.024 0.556 View mutations
261 V 13 6 19 0.308 0.476 View mutations
262 P 0 19 19 0.958 0.441 View mutations
263 E 17 2 19 0.125 0.509 View mutations
264 M 16 3 19 0.204 0.458 View mutations
265 E 19 0 19 0.006 0.742 View mutations
266 E 19 0 19 0.002 0.635 View mutations
267 S 19 0 19 0.035 0.686 View mutations
268 G 19 0 19 0.007 0.511 View mutations
269 A 19 0 19 0.032 0.673 View mutations
270 Q 19 0 19 0.002 0.745 View mutations
271 L 7 12 19 0.599 0.441 View mutations
272 L 19 0 19 0.000 0.397 View mutations
273 L 19 0 19 0.001 0.513 View mutations
274 E 6 13 19 0.623 0.387 View mutations
275 M 19 0 19 0.000 0.526 View mutations