P11802 (CDK4)

Overview
Predicted structure (AF):
AF-P11802-F1-model_v4
Uniprot entry:
P11802
Gene:
CDK4
Protein length:
303 residues
Mutations found:
5756
Benign based on D2Deep prediction:
3605 out of 5756 mutations
Pathogenic based on D2Deep prediction:
2151 out of 5756 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5756 mutations across 303 unique positions. There are 3605 benign and 2151 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
226 I 6 13 19 0.684 0.576 View mutations
227 F 19 0 19 0.001 0.383 View mutations
228 D 17 2 19 0.133 0.485 View mutations
229 L 3 16 19 0.839 0.470 View mutations
230 I 15 4 19 0.316 0.476 View mutations
231 G 17 2 19 0.137 0.341 View mutations
232 L 13 6 19 0.346 0.412 View mutations
233 P 0 19 19 1.000 0.614 View mutations
234 P 15 4 19 0.242 0.558 View mutations
235 E 18 1 19 0.038 0.466 View mutations
236 D 19 0 19 0.000 0.418 View mutations
237 D 1 18 19 0.946 0.452 View mutations
238 W 0 19 19 0.999 0.506 View mutations
239 P 0 19 19 0.996 0.567 View mutations
240 R 18 1 19 0.056 0.665 View mutations
241 D 12 7 19 0.403 0.496 View mutations
242 V 18 1 19 0.107 0.427 View mutations
243 S 19 0 19 0.027 0.546 View mutations
244 L 19 0 19 0.001 0.536 View mutations
245 P 17 2 19 0.089 0.556 View mutations
246 R 19 0 19 0.017 0.688 View mutations
247 G 19 0 19 0.004 0.658 View mutations
248 A 19 0 19 0.031 0.595 View mutations
249 F 15 4 19 0.284 0.517 View mutations
250 P 19 0 19 0.001 0.698 View mutations