P15976 (GATA1)

Overview
Predicted structure (AF):
AF-P15976-F1-model_v4
Uniprot entry:
P15976
Gene:
GATA1
Protein length:
413 residues
Mutations found:
7846
Benign based on D2Deep prediction:
3634 out of 7846 mutations
Pathogenic based on D2Deep prediction:
4212 out of 7846 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 7846 mutations across 413 unique positions. There are 3634 benign and 4212 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
1 M 1 17 18 0.883 0.420 View mutations
2 E 1 18 19 0.905 0.409 View mutations
3 F 1 18 19 0.965 0.361 View mutations
4 P 13 6 19 0.378 0.509 View mutations
5 G 17 2 19 0.100 0.492 View mutations
6 L 17 2 19 0.155 0.565 View mutations
7 G 19 0 19 0.009 0.505 View mutations
8 S 18 1 19 0.073 0.538 View mutations
9 L 16 3 19 0.183 0.501 View mutations
10 G 17 2 19 0.147 0.482 View mutations
11 T 19 0 19 0.018 0.675 View mutations
12 S 9 10 19 0.498 0.448 View mutations
13 E 18 1 19 0.109 0.502 View mutations
14 P 17 2 19 0.159 0.611 View mutations
15 L 19 0 19 0.006 0.612 View mutations
16 P 19 0 19 0.004 0.530 View mutations
17 Q 13 6 19 0.320 0.494 View mutations
18 F 15 4 19 0.274 0.500 View mutations
19 V 7 12 19 0.570 0.416 View mutations
20 D 8 11 19 0.521 0.432 View mutations
21 P 5 14 19 0.721 0.387 View mutations
22 A 16 3 19 0.211 0.567 View mutations
23 L 6 13 19 0.652 0.391 View mutations
24 V 5 14 19 0.730 0.379 View mutations
25 S 3 16 19 0.821 0.283 View mutations