P16410 (CTLA4)

Overview
Predicted structure (AF):
AF-P16410-F1-model_v4
Uniprot entry:
P16410
Gene:
CTLA4
Protein length:
223 residues
Mutations found:
4236
Benign based on D2Deep prediction:
2742 out of 4236 mutations
Pathogenic based on D2Deep prediction:
1494 out of 4236 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4236 mutations across 223 unique positions. There are 2742 benign and 1494 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
1 M 18 0 18 0.011 0.474 View mutations
2 A 19 0 19 0.004 0.605 View mutations
3 C 12 7 19 0.405 0.548 View mutations
4 L 19 0 19 0.031 0.744 View mutations
5 G 19 0 19 0.001 0.576 View mutations
6 F 19 0 19 0.010 0.802 View mutations
7 Q 19 0 19 0.001 0.865 View mutations
8 R 19 0 19 0.003 0.891 View mutations
9 H 19 0 19 0.001 0.970 View mutations
10 K 19 0 19 0.002 0.934 View mutations
11 A 19 0 19 0.002 0.803 View mutations
12 Q 19 0 19 0.001 0.981 View mutations
13 L 19 0 19 0.018 0.939 View mutations
14 N 19 0 19 0.005 0.931 View mutations
15 L 19 0 19 0.008 1.000 View mutations
16 A 19 0 19 0.001 0.891 View mutations
17 T 19 0 19 0.027 0.913 View mutations
18 R 19 0 19 0.045 0.800 View mutations
19 T 18 1 19 0.069 0.751 View mutations
20 W 19 0 19 0.022 0.841 View mutations
21 P 18 1 19 0.071 0.657 View mutations
22 C 19 0 19 0.036 0.768 View mutations
23 T 19 0 19 0.051 0.785 View mutations
24 L 19 0 19 0.079 0.709 View mutations
25 L 16 3 19 0.299 0.607 View mutations