P16410 (CTLA4)

Overview
Predicted structure (AF):
AF-P16410-F1-model_v4
Uniprot entry:
P16410
Gene:
CTLA4
Protein length:
223 residues
Mutations found:
4236
Benign based on D2Deep prediction:
2742 out of 4236 mutations
Pathogenic based on D2Deep prediction:
1494 out of 4236 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4236 mutations across 223 unique positions. There are 2742 benign and 1494 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 R 2 17 19 0.882 0.595 View mutations
52 G 5 14 19 0.800 0.599 View mutations
53 I 9 10 19 0.533 0.504 View mutations
54 A 0 19 19 0.949 0.718 View mutations
55 S 18 1 19 0.079 0.464 View mutations
56 F 19 0 19 0.094 0.396 View mutations
57 V 16 3 19 0.176 0.415 View mutations
58 C 14 5 19 0.360 0.457 View mutations
59 E 17 2 19 0.144 0.417 View mutations
60 Y 5 14 19 0.707 0.502 View mutations
61 A 18 1 19 0.105 0.589 View mutations
62 S 5 14 19 0.677 0.412 View mutations
63 P 13 6 19 0.279 0.529 View mutations
64 G 10 9 19 0.527 0.459 View mutations
65 K 16 3 19 0.193 0.635 View mutations
66 A 18 1 19 0.079 0.540 View mutations
67 T 16 3 19 0.183 0.547 View mutations
68 E 13 6 19 0.356 0.485 View mutations
69 V 7 12 19 0.648 0.527 View mutations
70 R 1 18 19 0.859 0.623 View mutations
71 V 2 17 19 0.820 0.677 View mutations
72 T 14 5 19 0.344 0.398 View mutations
73 V 0 19 19 0.982 0.651 View mutations
74 L 7 12 19 0.648 0.521 View mutations
75 R 0 19 19 0.934 0.520 View mutations