P16410 (CTLA4)

Overview
Predicted structure (AF):
AF-P16410-F1-model_v4
Uniprot entry:
P16410
Gene:
CTLA4
Protein length:
223 residues
Mutations found:
4236
Benign based on D2Deep prediction:
2742 out of 4236 mutations
Pathogenic based on D2Deep prediction:
1494 out of 4236 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4236 mutations across 223 unique positions. There are 2742 benign and 1494 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
26 F 19 0 19 0.030 0.684 View mutations
27 F 19 0 19 0.006 0.605 View mutations
28 L 13 6 19 0.292 0.525 View mutations
29 L 19 0 19 0.084 0.546 View mutations
30 F 19 0 19 0.009 0.619 View mutations
31 I 14 5 19 0.296 0.515 View mutations
32 P 19 0 19 0.000 0.472 View mutations
33 V 15 4 19 0.215 0.601 View mutations
34 F 16 3 19 0.151 0.504 View mutations
35 C 19 0 19 0.033 0.697 View mutations
36 K 19 0 19 0.006 0.567 View mutations
37 A 19 0 19 0.001 0.457 View mutations
38 M 14 5 19 0.332 0.407 View mutations
39 H 17 2 19 0.095 0.523 View mutations
40 V 17 2 19 0.137 0.344 View mutations
41 A 19 0 19 0.038 0.484 View mutations
42 Q 19 0 19 0.055 0.276 View mutations
43 P 17 2 19 0.194 0.301 View mutations
44 A 5 14 19 0.675 0.563 View mutations
45 V 16 3 19 0.213 0.299 View mutations
46 V 12 7 19 0.394 0.401 View mutations
47 L 6 13 19 0.599 0.600 View mutations
48 A 3 16 19 0.765 0.714 View mutations
49 S 4 15 19 0.713 0.594 View mutations
50 S 1 18 19 0.938 0.546 View mutations