P16410 (CTLA4)

Overview
Predicted structure (AF):
AF-P16410-F1-model_v4
Uniprot entry:
P16410
Gene:
CTLA4
Protein length:
223 residues
Mutations found:
4236
Benign based on D2Deep prediction:
2742 out of 4236 mutations
Pathogenic based on D2Deep prediction:
1494 out of 4236 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4236 mutations across 223 unique positions. There are 2742 benign and 1494 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
201 Y 0 19 19 1.000 0.773 View mutations
202 V 3 16 19 0.836 0.842 View mutations
203 K 2 17 19 0.856 0.752 View mutations
204 M 3 16 19 0.840 0.813 View mutations
205 P 0 19 19 0.935 0.983 View mutations
206 P 4 15 19 0.763 0.741 View mutations
207 T 13 6 19 0.339 0.405 View mutations
208 E 1 18 19 0.849 0.868 View mutations
209 P 6 13 19 0.619 0.659 View mutations
210 E 2 17 19 0.860 0.840 View mutations
211 C 10 9 19 0.455 0.482 View mutations
212 E 1 18 19 0.934 0.900 View mutations
213 K 0 19 19 0.939 0.792 View mutations
214 Q 0 19 19 0.922 0.778 View mutations
215 F 0 19 19 0.978 0.973 View mutations
216 Q 0 19 19 0.951 0.804 View mutations
217 P 2 17 19 0.770 0.886 View mutations
218 Y 19 0 19 0.183 0.158 View mutations
219 F 12 7 19 0.435 0.380 View mutations
220 I 16 3 19 0.254 0.176 View mutations
221 P 16 3 19 0.206 0.180 View mutations
222 I 19 0 19 0.039 0.114 View mutations
223 N 19 0 19 0.041 0.228 View mutations