P16410 (CTLA4)

Overview
Predicted structure (AF):
AF-P16410-F1-model_v4
Uniprot entry:
P16410
Gene:
CTLA4
Protein length:
223 residues
Mutations found:
4236
Benign based on D2Deep prediction:
2742 out of 4236 mutations
Pathogenic based on D2Deep prediction:
1494 out of 4236 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4236 mutations across 223 unique positions. There are 2742 benign and 1494 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
151 V 5 14 19 0.676 0.668 View mutations
152 I 11 8 19 0.471 0.456 View mutations
153 D 12 7 19 0.387 0.435 View mutations
154 P 18 1 19 0.093 0.376 View mutations
155 E 3 16 19 0.712 0.628 View mutations
156 P 16 3 19 0.231 0.414 View mutations
157 C 16 3 19 0.282 0.407 View mutations
158 P 11 8 19 0.432 0.470 View mutations
159 D 2 17 19 0.874 0.619 View mutations
160 S 11 8 19 0.368 0.499 View mutations
161 D 4 15 19 0.753 0.523 View mutations
162 F 6 13 19 0.702 0.446 View mutations
163 L 12 7 19 0.417 0.498 View mutations
164 L 13 6 19 0.320 0.465 View mutations
165 W 12 7 19 0.326 0.478 View mutations
166 I 2 17 19 0.851 0.456 View mutations
167 L 2 17 19 0.825 0.573 View mutations
168 A 9 10 19 0.447 0.505 View mutations
169 A 11 8 19 0.411 0.496 View mutations
170 V 7 12 19 0.562 0.524 View mutations
171 S 7 12 19 0.587 0.539 View mutations
172 S 19 0 19 0.033 0.335 View mutations
173 G 17 2 19 0.154 0.372 View mutations
174 L 19 0 19 0.092 0.292 View mutations
175 F 16 3 19 0.218 0.381 View mutations