P16410 (CTLA4)

Overview
Predicted structure (AF):
AF-P16410-F1-model_v4
Uniprot entry:
P16410
Gene:
CTLA4
Protein length:
223 residues
Mutations found:
4236
Benign based on D2Deep prediction:
2742 out of 4236 mutations
Pathogenic based on D2Deep prediction:
1494 out of 4236 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4236 mutations across 223 unique positions. There are 2742 benign and 1494 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
176 F 19 0 19 0.038 0.306 View mutations
177 Y 18 1 19 0.086 0.313 View mutations
178 S 19 0 19 0.021 0.273 View mutations
179 F 16 3 19 0.186 0.395 View mutations
180 L 10 9 19 0.413 0.490 View mutations
181 L 19 0 19 0.028 0.273 View mutations
182 T 19 0 19 0.018 0.235 View mutations
183 A 17 2 19 0.260 0.354 View mutations
184 V 9 10 19 0.466 0.515 View mutations
185 S 19 0 19 0.006 0.252 View mutations
186 L 15 4 19 0.242 0.347 View mutations
187 S 12 7 19 0.362 0.444 View mutations
188 K 13 6 19 0.391 0.435 View mutations
189 M 18 1 19 0.096 0.297 View mutations
190 L 3 16 19 0.713 0.661 View mutations
191 K 1 18 19 0.949 0.556 View mutations
192 K 2 17 19 0.831 0.609 View mutations
193 R 0 19 19 0.978 0.702 View mutations
194 S 0 19 19 0.989 0.736 View mutations
195 P 6 13 19 0.594 0.604 View mutations
196 L 6 13 19 0.704 0.637 View mutations
197 T 4 15 19 0.769 0.658 View mutations
198 T 1 18 19 0.930 0.763 View mutations
199 G 0 19 19 0.983 0.903 View mutations
200 V 3 16 19 0.803 0.794 View mutations