P25445 (P25445)

Overview
Predicted structure (AF):
AF-P25445-F1-model_v4
Uniprot entry:
P25445
Gene:
P25445
Protein length:
335 residues
Mutations found:
6364
Benign based on D2Deep prediction:
4666 out of 6364 mutations
Pathogenic based on D2Deep prediction:
1698 out of 6364 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 6364 mutations across 335 unique positions. There are 4666 benign and 1698 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
1 M 18 0 18 0.002 0.659 View mutations
2 L 19 0 19 0.001 0.833 View mutations
3 G 19 0 19 0.016 0.833 View mutations
4 I 19 0 19 0.004 0.822 View mutations
5 W 19 0 19 0.015 0.826 View mutations
6 T 19 0 19 0.001 0.833 View mutations
7 L 19 0 19 0.000 0.814 View mutations
8 L 19 0 19 0.000 0.814 View mutations
9 P 19 0 19 0.016 0.825 View mutations
10 L 19 0 19 0.002 0.829 View mutations
11 V 18 1 19 0.034 0.722 View mutations
12 L 16 3 19 0.124 0.656 View mutations
13 T 19 0 19 0.017 0.834 View mutations
14 S 19 0 19 0.001 0.821 View mutations
15 V 19 0 19 0.002 0.804 View mutations
16 A 19 0 19 0.000 0.800 View mutations
17 R 19 0 19 0.003 0.754 View mutations
18 L 19 0 19 0.006 0.828 View mutations
19 S 19 0 19 0.004 0.778 View mutations
20 S 19 0 19 0.001 0.793 View mutations
21 K 18 1 19 0.071 0.781 View mutations
22 S 19 0 19 0.012 0.760 View mutations
23 V 19 0 19 0.009 0.823 View mutations
24 N 18 1 19 0.094 0.703 View mutations
25 A 14 5 19 0.263 0.573 View mutations