P25445 (P25445)

Overview
Predicted structure (AF):
AF-P25445-F1-model_v4
Uniprot entry:
P25445
Gene:
P25445
Protein length:
335 residues
Mutations found:
6364
Benign based on D2Deep prediction:
4666 out of 6364 mutations
Pathogenic based on D2Deep prediction:
1698 out of 6364 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 6364 mutations across 335 unique positions. There are 4666 benign and 1698 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 G 3 16 19 0.802 0.418 View mutations
52 L 10 9 19 0.465 0.452 View mutations
53 H 7 12 19 0.615 0.425 View mutations
54 H 16 3 19 0.174 0.496 View mutations
55 D 16 3 19 0.181 0.557 View mutations
56 G 5 14 19 0.710 0.403 View mutations
57 Q 15 4 19 0.322 0.547 View mutations
58 F 17 2 19 0.139 0.445 View mutations
59 C 1 18 19 0.925 0.367 View mutations
60 H 14 5 19 0.293 0.479 View mutations
61 K 8 11 19 0.555 0.434 View mutations
62 P 5 14 19 0.724 0.535 View mutations
63 C 3 16 19 0.886 0.528 View mutations
64 P 19 0 19 0.014 0.409 View mutations
65 P 16 3 19 0.192 0.464 View mutations
66 G 11 8 19 0.451 0.482 View mutations
67 E 8 11 19 0.480 0.437 View mutations
68 R 15 4 19 0.262 0.476 View mutations
69 K 18 1 19 0.050 0.462 View mutations
70 A 19 0 19 0.034 0.482 View mutations
71 R 16 3 19 0.257 0.380 View mutations
72 D 18 1 19 0.066 0.368 View mutations
73 C 0 19 19 0.971 0.519 View mutations
74 T 14 5 19 0.253 0.452 View mutations
75 V 18 1 19 0.062 0.460 View mutations