P40337 (VHL)

Overview
Predicted structure (AF):
AF-P40337-F1-model_v4
Uniprot entry:
P40337
Gene:
VHL
Protein length:
213 residues
Mutations found:
4046
Benign based on D2Deep prediction:
2780 out of 4046 mutations
Pathogenic based on D2Deep prediction:
1266 out of 4046 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4046 mutations across 213 unique positions. There are 2780 benign and 1266 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
201 L 17 2 19 0.161 0.412 View mutations
202 T 12 7 19 0.339 0.492 View mutations
203 Q 18 1 19 0.050 0.497 View mutations
204 E 19 0 19 0.034 0.466 View mutations
205 R 19 0 19 0.003 0.520 View mutations
206 I 18 1 19 0.094 0.513 View mutations
207 A 19 0 19 0.028 0.594 View mutations
208 H 17 2 19 0.162 0.675 View mutations
209 Q 18 1 19 0.074 0.659 View mutations
210 R 19 0 19 0.007 0.758 View mutations
211 M 19 0 19 0.003 0.746 View mutations
212 G 4 15 19 0.697 0.321 View mutations
213 D 15 4 19 0.179 0.576 View mutations