P40337 (VHL)

Overview
Predicted structure (AF):
AF-P40337-F1-model_v4
Uniprot entry:
P40337
Gene:
VHL
Protein length:
213 residues
Mutations found:
4046
Benign based on D2Deep prediction:
2780 out of 4046 mutations
Pathogenic based on D2Deep prediction:
1266 out of 4046 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4046 mutations across 213 unique positions. There are 2780 benign and 1266 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
176 R 19 0 19 0.002 0.180 View mutations
177 R 17 2 19 0.120 0.291 View mutations
178 L 19 0 19 0.038 0.122 View mutations
179 D 19 0 19 0.002 0.029 View mutations
180 I 19 0 19 0.018 0.063 View mutations
181 V 19 0 19 0.009 0.159 View mutations
182 R 17 2 19 0.112 0.264 View mutations
183 S 19 0 19 0.010 0.018 View mutations
184 L 11 8 19 0.352 0.432 View mutations
185 Y 19 0 19 0.016 0.178 View mutations
186 E 19 0 19 0.002 0.191 View mutations
187 D 7 12 19 0.578 0.594 View mutations
188 L 10 9 19 0.448 0.479 View mutations
189 E 18 1 19 0.113 0.193 View mutations
190 D 14 5 19 0.265 0.306 View mutations
191 H 8 11 19 0.580 0.525 View mutations
192 P 4 15 19 0.749 0.714 View mutations
193 N 18 1 19 0.119 0.353 View mutations
194 V 7 12 19 0.559 0.562 View mutations
195 Q 18 1 19 0.090 0.485 View mutations
196 K 18 1 19 0.067 0.415 View mutations
197 D 4 15 19 0.681 0.612 View mutations
198 L 4 15 19 0.751 0.506 View mutations
199 E 18 1 19 0.048 0.488 View mutations
200 R 18 1 19 0.081 0.444 View mutations