P40337 (VHL)

Overview
Predicted structure (AF):
AF-P40337-F1-model_v4
Uniprot entry:
P40337
Gene:
VHL
Protein length:
213 residues
Mutations found:
4046
Benign based on D2Deep prediction:
2780 out of 4046 mutations
Pathogenic based on D2Deep prediction:
1266 out of 4046 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4046 mutations across 213 unique positions. There are 2780 benign and 1266 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
151 I 7 12 19 0.533 0.560 View mutations
152 T 9 10 19 0.547 0.512 View mutations
153 L 15 4 19 0.159 0.352 View mutations
154 P 18 1 19 0.146 0.254 View mutations
155 V 10 9 19 0.481 0.483 View mutations
156 Y 8 11 19 0.556 0.542 View mutations
157 T 12 7 19 0.481 0.406 View mutations
158 L 4 15 19 0.753 0.721 View mutations
159 K 1 18 19 0.917 0.799 View mutations
160 E 2 17 19 0.822 0.878 View mutations
161 R 6 13 19 0.664 0.638 View mutations
162 C 0 19 19 0.997 1.000 View mutations
163 L 0 19 19 0.970 0.918 View mutations
164 Q 4 15 19 0.686 0.653 View mutations
165 V 12 7 19 0.368 0.375 View mutations
166 V 7 12 19 0.601 0.622 View mutations
167 R 2 17 19 0.889 0.773 View mutations
168 S 18 1 19 0.147 0.156 View mutations
169 L 18 1 19 0.069 0.118 View mutations
170 V 7 12 19 0.573 0.607 View mutations
171 K 19 0 19 0.109 0.340 View mutations
172 P 19 0 19 0.007 0.085 View mutations
173 E 19 0 19 0.027 0.210 View mutations
174 N 18 1 19 0.079 0.241 View mutations
175 Y 18 1 19 0.061 0.143 View mutations