P40337 (VHL)

Overview
Predicted structure (AF):
AF-P40337-F1-model_v4
Uniprot entry:
P40337
Gene:
VHL
Protein length:
213 residues
Mutations found:
4046
Benign based on D2Deep prediction:
2780 out of 4046 mutations
Pathogenic based on D2Deep prediction:
1266 out of 4046 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4046 mutations across 213 unique positions. There are 2780 benign and 1266 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
1 M 0 18 18 0.962 0.336 View mutations
2 P 6 13 19 0.662 0.384 View mutations
3 R 15 4 19 0.318 0.621 View mutations
4 R 12 7 19 0.368 0.533 View mutations
5 A 19 0 19 0.018 0.669 View mutations
6 E 19 0 19 0.003 0.701 View mutations
7 N 19 0 19 0.007 0.809 View mutations
8 W 18 1 19 0.148 0.763 View mutations
9 D 19 0 19 0.038 0.858 View mutations
10 E 19 0 19 0.009 0.785 View mutations
11 A 19 0 19 0.002 0.810 View mutations
12 E 14 5 19 0.227 0.657 View mutations
13 V 18 1 19 0.085 0.849 View mutations
14 G 19 0 19 0.060 0.812 View mutations
15 A 19 0 19 0.006 0.863 View mutations
16 E 18 1 19 0.048 0.795 View mutations
17 E 19 0 19 0.001 0.895 View mutations
18 A 19 0 19 0.016 0.879 View mutations
19 G 14 5 19 0.252 0.704 View mutations
20 V 19 0 19 0.016 0.922 View mutations
21 E 14 5 19 0.237 0.693 View mutations
22 E 18 1 19 0.102 0.890 View mutations
23 Y 17 2 19 0.123 0.850 View mutations
24 G 10 9 19 0.407 0.520 View mutations
25 P 13 6 19 0.399 0.651 View mutations