P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
426 K 19 0 19 0.067 0.974 View mutations
427 L 19 0 19 0.002 1.000 View mutations
428 N 18 1 19 0.038 0.792 View mutations
429 E 19 0 19 0.012 0.797 View mutations
430 H 19 0 19 0.016 0.704 View mutations
431 F 15 4 19 0.255 0.437 View mutations
432 L 17 2 19 0.153 0.423 View mutations
433 N 19 0 19 0.000 0.591 View mutations
434 T 1 18 19 0.948 0.614 View mutations
435 T 19 0 19 0.008 0.591 View mutations
436 D 19 0 19 0.000 0.534 View mutations
437 F 19 0 19 0.000 0.411 View mutations
438 L 10 9 19 0.516 0.435 View mutations
439 D 19 0 19 0.000 0.665 View mutations
440 T 18 1 19 0.142 0.584 View mutations
441 I 4 15 19 0.791 0.517 View mutations
442 K 18 1 19 0.059 0.651 View mutations
443 S 18 1 19 0.066 0.721 View mutations
444 N 17 2 19 0.134 0.696 View mutations
445 L 18 1 19 0.111 0.496 View mutations
446 D 19 0 19 0.002 0.768 View mutations
447 R 19 0 19 0.020 0.812 View mutations
448 A 19 0 19 0.029 0.812 View mutations
449 L 19 0 19 0.015 0.707 View mutations
450 G 19 0 19 0.001 0.819 View mutations