P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
401 V 10 9 19 0.463 0.459 View mutations
402 C 17 2 19 0.132 0.443 View mutations
403 V 19 0 19 0.009 0.460 View mutations
404 E 17 2 19 0.116 0.667 View mutations
405 T 19 0 19 0.000 0.436 View mutations
406 V 19 0 19 0.000 0.287 View mutations
407 E 19 0 19 0.000 0.497 View mutations
408 S 19 0 19 0.071 0.591 View mutations
409 G 19 0 19 0.018 0.387 View mutations
410 A 19 0 19 0.017 0.622 View mutations
411 M 14 5 19 0.331 0.407 View mutations
412 T 0 19 19 1.000 0.733 View mutations
413 K 0 19 19 0.979 0.624 View mutations
414 D 4 15 19 0.691 0.585 View mutations
415 L 19 0 19 0.002 0.277 View mutations
416 A 0 19 19 0.996 0.524 View mutations
417 G 17 2 19 0.181 0.515 View mutations
418 C 19 0 19 0.007 0.549 View mutations
419 I 15 4 19 0.189 0.509 View mutations
420 H 12 7 19 0.305 0.558 View mutations
421 G 19 0 19 0.010 0.764 View mutations
422 L 19 0 19 0.001 0.865 View mutations
423 S 19 0 19 0.055 0.927 View mutations
424 N 19 0 19 0.031 0.964 View mutations
425 V 19 0 19 0.005 0.963 View mutations