P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
376 T 19 0 19 0.024 0.430 View mutations
377 R 9 10 19 0.509 0.437 View mutations
378 G 0 19 19 1.000 0.581 View mutations
379 L 11 8 19 0.436 0.488 View mutations
380 E 17 2 19 0.113 0.696 View mutations
381 H 18 1 19 0.086 0.538 View mutations
382 R 0 19 19 1.000 0.606 View mutations
383 G 1 18 19 0.938 0.448 View mutations
384 K 19 0 19 0.003 0.736 View mutations
385 L 17 2 19 0.126 0.464 View mutations
386 D 1 18 19 0.957 0.534 View mutations
387 G 18 1 19 0.064 0.645 View mutations
388 N 19 0 19 0.005 0.599 View mutations
389 Q 19 0 19 0.001 0.759 View mutations
390 D 19 0 19 0.001 0.698 View mutations
391 L 5 14 19 0.701 0.523 View mutations
392 I 19 0 19 0.021 0.780 View mutations
393 R 19 0 19 0.020 0.851 View mutations
394 F 8 11 19 0.581 0.436 View mutations
395 A 19 0 19 0.000 0.547 View mutations
396 Q 19 0 19 0.005 0.801 View mutations
397 M 19 0 19 0.013 0.835 View mutations
398 L 2 17 19 0.896 0.618 View mutations
399 E 19 0 19 0.019 0.403 View mutations
400 K 18 1 19 0.044 0.733 View mutations