P48735 (IDH2)

Overview
Predicted structure (AF):
AF-P48735-F1-model_v4
Uniprot entry:
P48735
Gene:
IDH2
Protein length:
452 residues
Mutations found:
8587
Benign based on D2Deep prediction:
5112 out of 8587 mutations
Pathogenic based on D2Deep prediction:
3475 out of 8587 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 8587 mutations across 452 unique positions. There are 5112 benign and 3475 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
76 D 9 10 19 0.554 0.442 View mutations
77 I 16 3 19 0.184 0.525 View mutations
78 Q 18 1 19 0.095 0.640 View mutations
79 L 18 1 19 0.082 0.477 View mutations
80 K 15 4 19 0.213 0.597 View mutations
81 Y 18 1 19 0.086 0.385 View mutations
82 F 3 16 19 0.847 0.416 View mutations
83 D 0 19 19 0.992 0.543 View mutations
84 L 16 3 19 0.210 0.480 View mutations
85 G 12 7 19 0.396 0.440 View mutations
86 L 18 1 19 0.045 0.461 View mutations
87 P 18 1 19 0.094 0.580 View mutations
88 N 16 3 19 0.194 0.613 View mutations
89 R 11 8 19 0.407 0.479 View mutations
90 D 19 0 19 0.001 0.435 View mutations
91 Q 19 0 19 0.011 0.578 View mutations
92 T 19 0 19 0.000 0.423 View mutations
93 D 15 4 19 0.329 0.405 View mutations
94 D 17 2 19 0.123 0.383 View mutations
95 Q 6 13 19 0.613 0.396 View mutations
96 V 2 17 19 0.914 0.577 View mutations
97 T 1 18 19 0.943 0.634 View mutations
98 I 14 5 19 0.267 0.417 View mutations
99 D 1 18 19 0.879 0.368 View mutations
100 S 2 17 19 0.914 0.481 View mutations