P51580 (TPMT)

Overview
Predicted structure (AF):
AF-P51580-F1-model_v4
Uniprot entry:
P51580
Gene:
TPMT
Protein length:
245 residues
Mutations found:
4654
Benign based on D2Deep prediction:
2752 out of 4654 mutations
Pathogenic based on D2Deep prediction:
1902 out of 4654 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4654 mutations across 245 unique positions. There are 2752 benign and 1902 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
226 R 16 3 19 0.217 0.539 View mutations
227 H 19 0 19 0.000 0.448 View mutations
228 K 15 4 19 0.230 0.503 View mutations
229 S 13 6 19 0.366 0.523 View mutations
230 W 0 19 19 0.864 0.483 View mutations
231 G 18 1 19 0.081 0.418 View mutations
232 I 15 4 19 0.223 0.471 View mutations
233 D 1 18 19 0.948 0.535 View mutations
234 C 4 15 19 0.730 0.428 View mutations
235 L 19 0 19 0.006 0.480 View mutations
236 F 19 0 19 0.000 0.480 View mutations
237 E 1 18 19 0.881 0.560 View mutations
238 K 16 3 19 0.199 0.518 View mutations
239 L 3 16 19 0.819 0.450 View mutations
240 Y 5 14 19 0.753 0.418 View mutations
241 L 18 1 19 0.108 0.486 View mutations
242 L 8 11 19 0.611 0.433 View mutations
243 T 13 6 19 0.337 0.509 View mutations
244 E 19 0 19 0.029 0.606 View mutations
245 K 8 11 19 0.563 0.431 View mutations