P51580 (TPMT)

Overview
Predicted structure (AF):
AF-P51580-F1-model_v4
Uniprot entry:
P51580
Gene:
TPMT
Protein length:
245 residues
Mutations found:
4654
Benign based on D2Deep prediction:
2752 out of 4654 mutations
Pathogenic based on D2Deep prediction:
1902 out of 4654 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4654 mutations across 245 unique positions. There are 2752 benign and 1902 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
201 H 19 0 19 0.005 0.546 View mutations
202 A 19 0 19 0.024 0.570 View mutations
203 E 18 1 19 0.088 0.477 View mutations
204 I 19 0 19 0.000 0.459 View mutations
205 E 19 0 19 0.017 0.641 View mutations
206 R 15 4 19 0.255 0.539 View mutations
207 L 7 12 19 0.625 0.506 View mutations
208 F 16 3 19 0.192 0.487 View mutations
209 G 19 0 19 0.068 0.446 View mutations
210 K 19 0 19 0.002 0.666 View mutations
211 I 19 0 19 0.012 0.742 View mutations
212 C 11 8 19 0.461 0.466 View mutations
213 N 19 0 19 0.073 0.656 View mutations
214 I 17 2 19 0.178 0.558 View mutations
215 R 18 1 19 0.057 0.667 View mutations
216 C 12 7 19 0.387 0.518 View mutations
217 L 18 1 19 0.100 0.508 View mutations
218 E 5 14 19 0.705 0.413 View mutations
219 K 19 0 19 0.013 0.580 View mutations
220 V 19 0 19 0.000 0.536 View mutations
221 D 19 0 19 0.001 0.585 View mutations
222 A 18 1 19 0.052 0.563 View mutations
223 F 18 1 19 0.080 0.478 View mutations
224 E 18 1 19 0.049 0.576 View mutations
225 E 19 0 19 0.070 0.572 View mutations