P51580 (TPMT)

Overview
Predicted structure (AF):
AF-P51580-F1-model_v4
Uniprot entry:
P51580
Gene:
TPMT
Protein length:
245 residues
Mutations found:
4654
Benign based on D2Deep prediction:
2752 out of 4654 mutations
Pathogenic based on D2Deep prediction:
1902 out of 4654 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4654 mutations across 245 unique positions. There are 2752 benign and 1902 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
1 M 18 0 18 0.001 0.681 View mutations
2 D 19 0 19 0.012 0.970 View mutations
3 G 18 1 19 0.097 0.935 View mutations
4 T 18 1 19 0.050 0.909 View mutations
5 R 19 0 19 0.008 0.994 View mutations
6 T 19 0 19 0.014 0.910 View mutations
7 S 19 0 19 0.001 0.896 View mutations
8 L 19 0 19 0.001 0.923 View mutations
9 D 19 0 19 0.003 0.940 View mutations
10 I 19 0 19 0.002 0.964 View mutations
11 E 19 0 19 0.003 0.959 View mutations
12 E 17 2 19 0.102 0.852 View mutations
13 Y 18 1 19 0.082 0.947 View mutations
14 S 18 1 19 0.080 0.860 View mutations
15 D 19 0 19 0.001 0.898 View mutations
16 T 18 1 19 0.047 0.903 View mutations
17 E 16 3 19 0.145 0.753 View mutations
18 V 12 7 19 0.406 0.572 View mutations
19 Q 13 6 19 0.366 0.581 View mutations
20 K 16 3 19 0.151 0.666 View mutations
21 N 5 14 19 0.720 0.366 View mutations
22 Q 19 0 19 0.123 0.657 View mutations
23 V 11 8 19 0.437 0.468 View mutations
24 L 3 16 19 0.862 0.409 View mutations
25 T 7 12 19 0.634 0.421 View mutations