P51580 (TPMT)

Overview
Predicted structure (AF):
AF-P51580-F1-model_v4
Uniprot entry:
P51580
Gene:
TPMT
Protein length:
245 residues
Mutations found:
4654
Benign based on D2Deep prediction:
2752 out of 4654 mutations
Pathogenic based on D2Deep prediction:
1902 out of 4654 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4654 mutations across 245 unique positions. There are 2752 benign and 1902 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
176 K 19 0 19 0.002 0.609 View mutations
177 K 18 1 19 0.071 0.568 View mutations
178 F 19 0 19 0.002 0.495 View mutations
179 Q 19 0 19 0.003 0.575 View mutations
180 Y 12 7 19 0.413 0.479 View mutations
181 L 18 1 19 0.074 0.442 View mutations
182 L 13 6 19 0.292 0.484 View mutations
183 C 14 5 19 0.300 0.488 View mutations
184 V 16 3 19 0.209 0.411 View mutations
185 L 18 1 19 0.046 0.386 View mutations
186 S 19 0 19 0.001 0.429 View mutations
187 Y 1 18 19 0.940 0.685 View mutations
188 D 3 16 19 0.731 0.601 View mutations
189 P 1 18 19 0.962 0.675 View mutations
190 T 14 5 19 0.344 0.401 View mutations
191 K 11 8 19 0.433 0.497 View mutations
192 H 19 0 19 0.033 0.413 View mutations
193 P 19 0 19 0.001 0.486 View mutations
194 G 2 17 19 0.783 0.729 View mutations
195 P 3 16 19 0.685 0.728 View mutations
196 P 19 0 19 0.003 0.205 View mutations
197 F 18 1 19 0.139 0.249 View mutations
198 Y 8 11 19 0.581 0.539 View mutations
199 V 17 2 19 0.108 0.305 View mutations
200 P 5 14 19 0.723 0.521 View mutations