P61073 (CXCR4)

Overview
Predicted structure (AF):
AF-P61073-F1-model_v4
Uniprot entry:
P61073
Gene:
CXCR4
Protein length:
352 residues
Mutations found:
6687
Benign based on D2Deep prediction:
2592 out of 6687 mutations
Pathogenic based on D2Deep prediction:
4095 out of 6687 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 6687 mutations across 352 unique positions. There are 2592 benign and 4095 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
326 L 11 8 19 0.408 0.461 View mutations
327 K 7 12 19 0.639 0.427 View mutations
328 I 7 12 19 0.534 0.416 View mutations
329 L 16 3 19 0.124 0.540 View mutations
330 S 15 4 19 0.263 0.536 View mutations
331 K 1 18 19 0.893 0.302 View mutations
332 G 7 12 19 0.612 0.406 View mutations
333 K 11 8 19 0.425 0.472 View mutations
334 R 5 14 19 0.731 0.385 View mutations
335 G 19 0 19 0.000 0.608 View mutations
336 G 18 1 19 0.050 0.631 View mutations
337 H 19 0 19 0.000 0.565 View mutations
338 S 19 0 19 0.017 0.496 View mutations
339 S 19 0 19 0.001 0.393 View mutations
340 V 5 14 19 0.761 0.506 View mutations
341 S 19 0 19 0.035 0.484 View mutations
342 T 11 8 19 0.416 0.491 View mutations
343 E 0 19 19 0.982 0.679 View mutations
344 S 0 19 19 1.000 0.610 View mutations
345 E 5 14 19 0.780 0.580 View mutations
346 S 4 15 19 0.793 0.568 View mutations
347 S 0 19 19 1.000 0.612 View mutations
348 S 1 18 19 0.949 0.529 View mutations
349 F 3 16 19 0.855 0.512 View mutations
350 H 6 13 19 0.715 0.515 View mutations