Q06643 (TNFC)

Overview
Predicted structure (AF):
AF-Q06643-F1-model_v4
Uniprot entry:
Q06643
Gene:
TNFC
Protein length:
244 residues
Mutations found:
4635
Benign based on D2Deep prediction:
3101 out of 4635 mutations
Pathogenic based on D2Deep prediction:
1534 out of 4635 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 4635 mutations across 244 unique positions. There are 3101 benign and 1534 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
1 M 14 4 18 0.218 0.447 View mutations
2 G 10 9 19 0.494 0.463 View mutations
3 A 6 13 19 0.660 0.371 View mutations
4 L 17 2 19 0.131 0.714 View mutations
5 G 19 0 19 0.019 0.689 View mutations
6 L 19 0 19 0.003 0.738 View mutations
7 E 19 0 19 0.003 0.705 View mutations
8 G 19 0 19 0.002 0.706 View mutations
9 R 19 0 19 0.026 0.851 View mutations
10 G 17 2 19 0.164 0.735 View mutations
11 G 19 0 19 0.051 0.719 View mutations
12 R 16 3 19 0.235 0.626 View mutations
13 L 18 1 19 0.119 0.696 View mutations
14 Q 14 5 19 0.249 0.598 View mutations
15 G 19 0 19 0.005 0.768 View mutations
16 R 19 0 19 0.024 0.711 View mutations
17 G 8 11 19 0.548 0.429 View mutations
18 S 9 10 19 0.536 0.444 View mutations
19 L 13 6 19 0.348 0.491 View mutations
20 L 8 11 19 0.553 0.431 View mutations
21 L 4 15 19 0.776 0.380 View mutations
22 A 9 10 19 0.481 0.447 View mutations
23 V 6 13 19 0.718 0.403 View mutations
24 A 5 14 19 0.716 0.385 View mutations
25 G 0 19 19 0.982 0.354 View mutations