Q06643 (TNFC)

Overview
Predicted structure (AF):
AF-Q06643-F1-model_v4
Uniprot entry:
Q06643
Gene:
TNFC
Protein length:
244 residues
Mutations found:
4635
Benign based on D2Deep prediction:
3101 out of 4635 mutations
Pathogenic based on D2Deep prediction:
1534 out of 4635 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4635 mutations across 244 unique positions. There are 3101 benign and 1534 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 Q 1 18 19 0.935 0.227 View mutations
52 G 9 10 19 0.572 0.458 View mutations
53 G 8 11 19 0.574 0.426 View mutations
54 L 18 1 19 0.087 0.774 View mutations
55 V 19 0 19 0.004 0.758 View mutations
56 T 19 0 19 0.048 0.848 View mutations
57 E 9 10 19 0.606 0.466 View mutations
58 T 18 1 19 0.076 0.913 View mutations
59 A 18 1 19 0.094 0.860 View mutations
60 D 18 1 19 0.086 0.830 View mutations
61 P 16 3 19 0.226 0.800 View mutations
62 G 12 7 19 0.386 0.580 View mutations
63 A 18 1 19 0.084 0.865 View mutations
64 Q 18 1 19 0.062 0.852 View mutations
65 A 17 2 19 0.109 0.795 View mutations
66 Q 18 1 19 0.042 0.944 View mutations
67 Q 18 1 19 0.094 0.906 View mutations
68 G 18 1 19 0.058 0.915 View mutations
69 L 18 1 19 0.038 0.836 View mutations
70 G 19 0 19 0.008 0.917 View mutations
71 F 17 2 19 0.138 0.767 View mutations
72 Q 18 1 19 0.135 0.830 View mutations
73 K 17 2 19 0.130 0.814 View mutations
74 L 15 4 19 0.252 0.703 View mutations
75 P 17 2 19 0.150 0.754 View mutations