Q06643 (TNFC)

Overview
Predicted structure (AF):
AF-Q06643-F1-model_v4
Uniprot entry:
Q06643
Gene:
TNFC
Protein length:
244 residues
Mutations found:
4635
Benign based on D2Deep prediction:
3101 out of 4635 mutations
Pathogenic based on D2Deep prediction:
1534 out of 4635 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4635 mutations across 244 unique positions. There are 3101 benign and 1534 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
26 A 11 8 19 0.455 0.484 View mutations
27 T 9 10 19 0.473 0.448 View mutations
28 S 9 10 19 0.496 0.450 View mutations
29 L 6 13 19 0.738 0.422 View mutations
30 V 6 13 19 0.688 0.401 View mutations
31 T 8 11 19 0.581 0.432 View mutations
32 L 3 16 19 0.827 0.404 View mutations
33 L 0 19 19 0.986 0.382 View mutations
34 L 9 10 19 0.620 0.441 View mutations
35 A 6 13 19 0.697 0.409 View mutations
36 V 6 13 19 0.682 0.428 View mutations
37 P 1 18 19 0.931 0.432 View mutations
38 I 3 16 19 0.835 0.382 View mutations
39 T 6 13 19 0.678 0.429 View mutations
40 V 8 11 19 0.591 0.434 View mutations
41 L 1 18 19 0.927 0.378 View mutations
42 A 8 11 19 0.563 0.434 View mutations
43 V 12 7 19 0.408 0.450 View mutations
44 L 0 19 19 0.966 0.414 View mutations
45 A 1 18 19 0.933 0.360 View mutations
46 L 7 12 19 0.607 0.423 View mutations
47 V 19 0 19 0.088 0.579 View mutations
48 P 14 5 19 0.292 0.532 View mutations
49 Q 11 8 19 0.465 0.497 View mutations
50 D 12 7 19 0.385 0.530 View mutations