Q06643 (TNFC)

Overview
Predicted structure (AF):
AF-Q06643-F1-model_v4
Uniprot entry:
Q06643
Gene:
TNFC
Protein length:
244 residues
Mutations found:
4635
Benign based on D2Deep prediction:
3101 out of 4635 mutations
Pathogenic based on D2Deep prediction:
1534 out of 4635 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4635 mutations across 244 unique positions. There are 3101 benign and 1534 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
226 P 17 2 19 0.142 0.370 View mutations
227 D 10 9 19 0.424 0.495 View mutations
228 M 5 14 19 0.765 0.563 View mutations
229 V 0 19 19 1.000 0.741 View mutations
230 D 0 19 19 1.000 0.745 View mutations
231 F 2 17 19 0.868 0.609 View mutations
232 A 2 17 19 0.886 0.604 View mutations
233 R 0 19 19 1.000 0.700 View mutations
234 G 0 19 19 0.998 0.860 View mutations
235 K 2 17 19 0.880 0.731 View mutations
236 T 1 18 19 0.937 0.900 View mutations
237 F 4 15 19 0.769 0.687 View mutations
238 F 0 19 19 0.972 1.000 View mutations
239 G 0 19 19 0.985 0.994 View mutations
240 A 0 19 19 0.984 0.953 View mutations
241 V 2 17 19 0.858 0.874 View mutations
242 M 2 17 19 0.845 0.749 View mutations
243 V 2 17 19 0.895 0.775 View mutations
244 G 5 14 19 0.729 0.609 View mutations