Q06643 (TNFC)

Overview
Predicted structure (AF):
AF-Q06643-F1-model_v4
Uniprot entry:
Q06643
Gene:
TNFC
Protein length:
244 residues
Mutations found:
4635
Benign based on D2Deep prediction:
3101 out of 4635 mutations
Pathogenic based on D2Deep prediction:
1534 out of 4635 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 4635 mutations across 244 unique positions. There are 3101 benign and 1534 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
201 W 18 1 19 0.054 0.429 View mutations
202 Y 19 0 19 0.017 0.288 View mutations
203 T 19 0 19 0.004 0.275 View mutations
204 S 19 0 19 0.009 0.248 View mutations
205 V 18 1 19 0.054 0.150 View mutations
206 G 19 0 19 0.047 0.172 View mutations
207 F 13 6 19 0.338 0.383 View mutations
208 G 19 0 19 0.164 0.144 View mutations
209 G 15 4 19 0.212 0.293 View mutations
210 L 18 1 19 0.171 0.159 View mutations
211 V 18 1 19 0.070 0.206 View mutations
212 Q 0 19 19 0.981 0.686 View mutations
213 L 1 18 19 0.887 0.782 View mutations
214 R 1 18 19 0.884 0.625 View mutations
215 R 9 10 19 0.630 0.504 View mutations
216 G 5 14 19 0.686 0.622 View mutations
217 E 5 14 19 0.686 0.643 View mutations
218 R 19 0 19 0.006 0.454 View mutations
219 V 18 1 19 0.126 0.201 View mutations
220 Y 13 6 19 0.382 0.444 View mutations
221 V 19 0 19 0.003 0.106 View mutations
222 N 9 10 19 0.530 0.515 View mutations
223 I 16 3 19 0.113 0.307 View mutations
224 S 9 10 19 0.474 0.511 View mutations
225 H 18 1 19 0.062 0.371 View mutations