Q06643 (TNFC)

Overview
Predicted structure (AF):
AF-Q06643-F1-model_v4
Uniprot entry:
Q06643
Gene:
TNFC
Protein length:
244 residues
Mutations found:
4635
Benign based on D2Deep prediction:
3101 out of 4635 mutations
Pathogenic based on D2Deep prediction:
1534 out of 4635 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4635 mutations across 244 unique positions. There are 3101 benign and 1534 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
176 E 19 0 19 0.134 0.406 View mutations
177 L 7 12 19 0.489 0.523 View mutations
178 L 16 3 19 0.131 0.355 View mutations
179 L 11 8 19 0.367 0.468 View mutations
180 E 13 6 19 0.406 0.455 View mutations
181 G 18 1 19 0.122 0.331 View mutations
182 A 15 4 19 0.190 0.438 View mutations
183 E 16 3 19 0.255 0.396 View mutations
184 T 13 6 19 0.313 0.484 View mutations
185 V 19 0 19 0.004 0.487 View mutations
186 T 19 0 19 0.000 0.624 View mutations
187 P 19 0 19 0.000 0.609 View mutations
188 V 19 0 19 0.001 0.688 View mutations
189 L 19 0 19 0.072 0.724 View mutations
190 D 19 0 19 0.024 0.824 View mutations
191 P 19 0 19 0.002 0.880 View mutations
192 A 19 0 19 0.017 0.910 View mutations
193 R 19 0 19 0.005 0.910 View mutations
194 R 19 0 19 0.028 0.915 View mutations
195 Q 19 0 19 0.001 0.875 View mutations
196 G 19 0 19 0.001 0.813 View mutations
197 Y 19 0 19 0.004 0.742 View mutations
198 G 17 2 19 0.180 0.598 View mutations
199 P 16 3 19 0.167 0.517 View mutations
200 L 4 15 19 0.709 0.452 View mutations