O43543 (XRCC2)

Overview
Predicted structure (AF):
AF-O43543-F1-model_v4
Uniprot entry:
O43543
Gene:
XRCC2
Protein length:
280 residues
Mutations found:
5319
Benign based on D2Deep prediction:
2575 out of 5319 mutations
Pathogenic based on D2Deep prediction:
2744 out of 5319 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5319 mutations across 280 unique positions. There are 2575 benign and 2744 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
251 N 16 3 19 0.197 0.757 View mutations
252 Q 15 4 19 0.181 0.683 View mutations
253 F 2 17 19 0.829 0.268 View mutations
254 S 18 1 19 0.096 0.705 View mutations
255 L 3 16 19 0.801 0.300 View mutations
256 V 6 13 19 0.713 0.373 View mutations
257 S 6 13 19 0.604 0.381 View mutations
258 R 10 9 19 0.443 0.482 View mutations
259 C 5 14 19 0.674 0.351 View mutations
260 L 16 3 19 0.137 0.590 View mutations
261 K 12 7 19 0.433 0.523 View mutations
262 S 3 16 19 0.836 0.295 View mutations
263 N 18 1 19 0.084 0.699 View mutations
264 S 8 11 19 0.529 0.427 View mutations
265 L 18 1 19 0.082 0.691 View mutations
266 K 18 1 19 0.049 0.680 View mutations
267 K 4 15 19 0.785 0.363 View mutations
268 H 15 4 19 0.203 0.541 View mutations
269 F 16 3 19 0.132 0.603 View mutations
270 F 0 19 19 0.990 0.451 View mutations
271 I 18 1 19 0.078 0.625 View mutations
272 I 15 4 19 0.218 0.414 View mutations
273 G 15 4 19 0.192 0.495 View mutations
274 E 4 15 19 0.745 0.445 View mutations
275 S 18 1 19 0.056 0.431 View mutations