O43543 (XRCC2)

Overview
Predicted structure (AF):
AF-O43543-F1-model_v4
Uniprot entry:
O43543
Gene:
XRCC2
Protein length:
280 residues
Mutations found:
5319
Benign based on D2Deep prediction:
2575 out of 5319 mutations
Pathogenic based on D2Deep prediction:
2744 out of 5319 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5319 mutations across 280 unique positions. There are 2575 benign and 2744 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
226 Y 2 17 19 0.904 0.695 View mutations
227 L 12 7 19 0.341 0.432 View mutations
228 C 4 15 19 0.792 0.595 View mutations
229 K 0 19 19 0.963 0.586 View mutations
230 A 6 13 19 0.683 0.524 View mutations
231 W 0 19 19 0.989 0.722 View mutations
232 Q 0 19 19 0.992 0.645 View mutations
233 Q 2 17 19 0.905 0.467 View mutations
234 L 3 16 19 0.803 0.457 View mutations
235 V 12 7 19 0.307 0.458 View mutations
236 K 19 0 19 0.000 0.479 View mutations
237 H 6 13 19 0.632 0.427 View mutations
238 R 0 19 19 1.000 0.583 View mutations
239 M 6 13 19 0.733 0.452 View mutations
240 F 15 4 19 0.222 0.484 View mutations
241 F 9 10 19 0.549 0.503 View mutations
242 S 11 8 19 0.411 0.426 View mutations
243 K 2 17 19 0.810 0.387 View mutations
244 Q 19 0 19 0.008 0.769 View mutations
245 D 17 2 19 0.109 0.692 View mutations
246 D 14 5 19 0.252 0.645 View mutations
247 S 19 0 19 0.006 0.782 View mutations
248 Q 17 2 19 0.087 0.731 View mutations
249 S 15 4 19 0.208 0.684 View mutations
250 S 17 2 19 0.153 0.738 View mutations