O43543 (XRCC2)

Overview
Predicted structure (AF):
AF-O43543-F1-model_v4
Uniprot entry:
O43543
Gene:
XRCC2
Protein length:
280 residues
Mutations found:
5319
Benign based on D2Deep prediction:
2575 out of 5319 mutations
Pathogenic based on D2Deep prediction:
2744 out of 5319 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5319 mutations across 280 unique positions. There are 2575 benign and 2744 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
26 E 7 12 19 0.617 0.412 View mutations
27 I 4 15 19 0.787 0.375 View mutations
28 E 2 17 19 0.855 0.393 View mutations
29 P 3 16 19 0.767 0.400 View mutations
30 N 16 3 19 0.185 0.658 View mutations
31 L 3 16 19 0.854 0.453 View mutations
32 F 1 18 19 0.943 0.381 View mutations
33 A 2 17 19 0.897 0.346 View mutations
34 D 10 9 19 0.448 0.461 View mutations
35 E 4 15 19 0.770 0.368 View mutations
36 D 19 0 19 0.024 0.646 View mutations
37 S 19 0 19 0.027 0.615 View mutations
38 P 0 19 19 0.990 0.376 View mutations
39 V 5 14 19 0.705 0.394 View mutations
40 H 10 9 19 0.387 0.455 View mutations
41 G 0 19 19 1.000 0.532 View mutations
42 D 10 9 19 0.464 0.434 View mutations
43 I 14 5 19 0.256 0.434 View mutations
44 L 2 17 19 0.883 0.537 View mutations
45 E 0 19 19 1.000 0.677 View mutations
46 F 0 19 19 0.985 0.647 View mutations
47 H 1 18 19 0.930 0.651 View mutations
48 G 0 19 19 0.999 0.682 View mutations
49 P 1 18 19 0.972 0.616 View mutations
50 E 0 19 19 1.000 0.779 View mutations