O43543 (XRCC2)

Overview
Predicted structure (AF):
AF-O43543-F1-model_v4
Uniprot entry:
O43543
Gene:
XRCC2
Protein length:
280 residues
Mutations found:
5319
Benign based on D2Deep prediction:
2575 out of 5319 mutations
Pathogenic based on D2Deep prediction:
2744 out of 5319 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 5319 mutations across 280 unique positions. There are 2575 benign and 2744 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
76 V 2 17 19 0.885 0.549 View mutations
77 E 6 13 19 0.668 0.513 View mutations
78 V 0 19 19 1.000 0.659 View mutations
79 L 5 14 19 0.726 0.507 View mutations
80 F 0 19 19 0.998 0.703 View mutations
81 I 1 18 19 0.919 0.744 View mutations
82 D 0 19 19 1.000 0.842 View mutations
83 T 1 18 19 0.929 0.898 View mutations
84 D 0 19 19 0.991 0.964 View mutations
85 Y 6 13 19 0.723 0.596 View mutations
86 H 14 5 19 0.339 0.319 View mutations
87 F 0 19 19 0.998 1.000 View mutations
88 D 1 18 19 0.819 0.900 View mutations
89 M 8 11 19 0.546 0.556 View mutations
90 L 19 0 19 0.049 0.092 View mutations
91 R 18 1 19 0.194 0.114 View mutations
92 L 15 4 19 0.228 0.310 View mutations
93 V 4 15 19 0.756 0.650 View mutations
94 T 12 7 19 0.411 0.447 View mutations
95 I 7 12 19 0.611 0.548 View mutations
96 L 5 14 19 0.770 0.595 View mutations
97 E 2 17 19 0.916 0.588 View mutations
98 H 15 4 19 0.261 0.459 View mutations
99 R 14 5 19 0.310 0.394 View mutations
100 L 10 9 19 0.477 0.445 View mutations