O75204 (TMEM127)

Overview
Predicted structure (AF):
AF-O75204-F1-model_v4
Uniprot entry:
O75204
Gene:
TMEM127
Protein length:
238 residues
Mutations found:
4521
Benign based on D2Deep prediction:
2714 out of 4521 mutations
Pathogenic based on D2Deep prediction:
1807 out of 4521 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

Download displayed results as CSV

Table results: 4521 mutations across 238 unique positions. There are 2714 benign and 1807 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
26 Q 16 3 19 0.180 0.510 View mutations
27 P 18 1 19 0.103 0.503 View mutations
28 E 19 0 19 0.036 0.393 View mutations
29 R 16 3 19 0.314 0.469 View mutations
30 S 15 4 19 0.238 0.451 View mutations
31 L 14 5 19 0.345 0.482 View mutations
32 A 14 5 19 0.263 0.496 View mutations
33 S 1 18 19 0.934 0.546 View mutations
34 A 8 11 19 0.587 0.517 View mutations
35 L 5 14 19 0.754 0.547 View mutations
36 P 0 19 19 0.999 0.428 View mutations
37 G 0 19 19 0.979 0.673 View mutations
38 A 0 19 19 0.977 0.592 View mutations
39 L 1 18 19 0.884 0.611 View mutations
40 S 0 19 19 0.992 0.645 View mutations
41 I 0 19 19 0.979 0.584 View mutations
42 T 4 15 19 0.786 0.545 View mutations
43 A 3 16 19 0.881 0.622 View mutations
44 L 0 19 19 0.999 0.689 View mutations
45 C 0 19 19 0.999 0.702 View mutations
46 T 3 16 19 0.842 0.588 View mutations
47 A 0 19 19 0.984 0.767 View mutations
48 L 1 18 19 0.947 0.731 View mutations
49 A 0 19 19 0.967 0.732 View mutations
50 E 1 18 19 0.903 0.614 View mutations