O75204 (TMEM127)

Overview
Predicted structure (AF):
AF-O75204-F1-model_v4
Uniprot entry:
O75204
Gene:
TMEM127
Protein length:
238 residues
Mutations found:
4521
Benign based on D2Deep prediction:
2714 out of 4521 mutations
Pathogenic based on D2Deep prediction:
1807 out of 4521 mutations
Scores that are greater than or equal to 0.5 are considered "Pathogenic", while scores that are less than 0.5 are considered "Benign".
Predicted structure
Mutation Scores
Long range effect of the mutations
Short range effect of the mutations

Positions

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Table results: 4521 mutations across 238 unique positions. There are 2714 benign and 1807 pathogenic mutations.

Position Original Benign Pathogenic Total D2Deep score mean Overall confidence mean Actions
51 P 0 19 19 0.992 0.675 View mutations
52 A 1 18 19 0.873 0.583 View mutations
53 W 0 19 19 0.996 0.575 View mutations
54 L 4 15 19 0.676 0.564 View mutations
55 H 18 1 19 0.143 0.433 View mutations
56 I 15 4 19 0.240 0.414 View mutations
57 H 2 17 19 0.863 0.466 View mutations
58 G 3 16 19 0.763 0.447 View mutations
59 G 5 14 19 0.665 0.445 View mutations
60 T 12 7 19 0.363 0.481 View mutations
61 C 0 19 19 0.995 0.299 View mutations
62 S 8 11 19 0.580 0.431 View mutations
63 R 4 15 19 0.739 0.380 View mutations
64 Q 7 12 19 0.616 0.426 View mutations
65 E 11 8 19 0.350 0.422 View mutations
66 L 6 13 19 0.687 0.439 View mutations
67 G 0 19 19 0.938 0.397 View mutations
68 V 2 17 19 0.888 0.420 View mutations
69 S 13 6 19 0.293 0.473 View mutations
70 D 7 12 19 0.658 0.433 View mutations
71 V 5 14 19 0.731 0.504 View mutations
72 L 3 16 19 0.837 0.460 View mutations
73 G 11 8 19 0.461 0.450 View mutations
74 Y 4 15 19 0.714 0.370 View mutations
75 V 9 10 19 0.505 0.444 View mutations